Free physician consultation·No insurance required·No auto-billing
⚡ Overnight Rebound · Physician-Prescribed

Overnight Rebound.
Build muscle. Burn fat. Sleep deeply again.

Sermorelin Peptide · Anti-aging protocol

Compounded Sermorelin acetate, personalized to your prescription, shipped cold-packed from a 503A licensed pharmacy. Stimulates your body’s own growth hormone — not synthetic HGH. No insurance. No auto-billing. 3-minute consultation.

  • Leaner body composition
  • Deeper, restorative sleep
  • Faster workout recovery
  • Smoother skin, fuller hair
$299
$99/mo
Overnight Rebound · Sermorelin
Multi-month savings available

Free physician review · No auto-billing · 100% refund if not approved

A CoreAge Rx patient holding her prescription Sermorelin vial
Before Sermorelin

We Heard This From Every Patient Before They Started:

None of it addressed why your body stopped repairing itself overnight.
Your growth hormone did.

Why Sermorelin

Here’s What Sermorelin Does That Synthetic HGH Can’t:

Stimulates your own pituitary — your body releases its own growth hormone, in its own rhythm, in its own dose. Not synthetic over-supply.
Released during deep sleep — Sermorelin times the pulse to when your body actually uses growth hormone for repair. Built-in timing.
Builds lean muscle mass — supports protein synthesis and muscle recovery at the cellular level. Workouts you used to barely tolerate start producing results again.
Activates fat metabolism — IGF-1 release increases lipolysis and metabolic rate. Body composition shifts even when the scale moves slowly.
Strengthens bones, joints, skin — direct effect on collagen production, bone density, and connective tissue integrity. Hair and nails follow.
Doesn’t shut down natural production — unlike synthetic HGH, Sermorelin works with your body’s feedback loop. Stop the protocol, your pituitary keeps firing.
Growth hormone levels decline by age — chart visualization
The Mechanism

Here’s The Problem...

Your pituitary gland produced about 500–700 micrograms of growth hormone per day in your 20s. By age 40, it’s making roughly a third of that. By 60, less than 10%.

Growth hormone is what tells your body to rebuild. Muscle after training. Skin after sun damage. Tissue after a hard day. When it drops, the rebuilding slows down with it.

This is why you can lift the same weight at 45 that you did at 25 and not see the same result. This is why you wake up sore from movements that used to be nothing. This is why the skin around your eyes started to look tired.

The fix isn’t synthetic HGH — that’s expensive, risky, and tells your pituitary to shut down. The fix is telling your pituitary to start producing again. That’s what Sermorelin does.

The Protocol

A daily injection (Mon–Fri) before bed. Your pituitary does the rest while you sleep.

Reviewed by a US Board-certified physician. Personalized prescription compounded at a 503A licensed pharmacy. Shipped cold-packed.

Starting at $99/month — no auto-billing, no escalators.

The CoreAge Rx Promise

Six Things We Won’t Compromise On

503A Licensed PharmacyUS Board-Certified PhysiciansCompounded Per PrescriptionHIPAA SecureCold Packed ShippingNo Auto-Billing
Male pharmacist preparing a personalized Sermorelin prescription at a 503A licensed compounding pharmacy
Where It’s Made

Personalized For You At A 503A Licensed Compounding Pharmacy

Compounded medications are not mass-produced. Each Sermorelin prescription is prepared individually for the patient it’s written for — your name, your dose, your protocol. The pharmacy’s name and license number appear on your prescription and on every vial we ship.

Our partner pharmacy is regulated by the state board of pharmacy as a 503A facility — the federal designation for licensed compounders preparing patient-specific medications. Sterility, potency, and purity are tested and documented for every prescription filled.

Your shipment is prepared the day it ships, packed cold, and delivered in temperature-controlled packaging. Discreet, unmarked exterior.

What To Expect

What Should I Expect From Consistent Sermorelin Therapy?

Sermorelin doesn’t work like a stimulant or a metabolic boost. It works like rebuilt sleep — and the changes that follow show up in the mirror, the scale, and your bloodwork, not in your morning energy.

Week 1–2

Sleep architecture rebuilds.

Sermorelin’s first effect is on the deep stages of sleep — where growth hormone is actually released. Sleep trackers register more Stage 3 sleep and longer REM cycles. You stop waking at 3am. Morning grogginess fades because the sleep itself changed, not because the mornings did.

Week 3–4

Recovery shortens.

The first physical change patients track. Workouts you needed three days to recover from now feel manageable in one. DOMS (delayed onset muscle soreness) is less brutal. You can train more often without crashing because your body is actually rebuilding overnight again.

Month 2

Body composition begins to shift.

Scale may not move much — but pants fit differently. Belt notches change. Lean mass is going up while fat percentage drops. If you do a DEXA scan at month 2, the body composition change is measurable even when the bathroom scale isn’t telling you much.

Month 3

Visible composition change.

Muscle definition you’d lost starts coming back — shoulders, arms, posture. Skin tone tightens. Joints feel less creaky in the mornings. The change is now visible in photos, not just in the mirror.

Month 6

The transformation milestone.

Significant body composition change. Sustained physical recovery. Skin elasticity improved. Hair fuller. Libido often returns. If your physician orders bloodwork, IGF-1 is measurably elevated — usually back into the upper half of the age-adjusted range. This is when most patients reach what they came for.

Month 12

Sustained anti-aging.

Body composition holds. Strength holds. Skin elasticity, hair fullness, and bone density support all maintained. Patients tell us “I stopped feeling like I was slipping” — which is the truer description than “I feel 25 again.” Sermorelin doesn’t reverse aging. It restores the rate at which your body keeps up with it.

Real Patients

Here’s What CoreAge Rx Patients Are Saying:

4.6 out of 5based on 2,000+ patient reviews
Verified patient Rachel T.
Rachel T. ✓ Verified
5 months on Overnight Rebound

The sleep alone was worth it by week two. I’ve been waking up before my alarm, refreshed, for the first time in maybe a decade. Five months in my workouts feel like I’m 35 again. Best money I’ve spent on my health.

Verified patient Mike K.
Mike K. ✓ Verified
3 months on Sermorelin

I priced out an anti-aging clinic that wanted $2,800/month for synthetic HGH. The doctor at CoreAge Rx walked me through why Sermorelin was a better fit for what I actually needed. Three months in, body composition has shifted more than two years of clean eating did.

Verified patient Linda S.
Linda S. ✓ Verified
4 months on Overnight Rebound

I was so nervous about injecting daily. The walkthrough video is two minutes. The needle is the size diabetics use. I felt it less than a flu shot. By week three I was doing it without thinking. My skin is the surprise — friends keep asking what changed.

Verified patient Daniel C.
Daniel C. ✓ Verified
7 months on Sermorelin

I’m 53. Six months in I bench-pressed my old high school PR for three reps. I don’t know how to describe what it feels like to get strength back that you’d written off. Worth every dollar. No auto-billing surprises either — I order when I need more.

Verified patient Jennifer P.
Jennifer P. ✓ Verified
10 weeks on Overnight Rebound

Week 1 I was skeptical. Week 4 my partner pointed out I’d stopped snoring. Week 8 my jeans were loose without me changing anything. Week 10 I look at photos of myself from January and don’t recognize the tired version. This is real.

Verified patient Becky V.
Becky V. ✓ Verified
12 months on Sermorelin

One year in. The clearest way I can describe it is: I stopped feeling old. The slowdown that I thought was just “being 50” turned out to be partially fixable. Sleep, energy, skin, mood, libido — all noticeably better. The pricing has never changed. Highly recommended.

Our Belief

Anti-aging medicine isn’t supposed to be priced like luxury. It shouldn’t cost $3,000 a month to feel like yourself again.

— The CoreAge Rx Medical Team
How To Use

From Box To Injection In Under 5 Minutes

A 90-second walkthrough video is in your patient portal. Your physician is one message away.

📦
Step 01

Receive your box

Cold-packed, discreet packaging. Refrigerate immediately on arrival.

🧴
Step 02

Prep your site

Don’t eat for 2–3 hours beforehand. Wash hands. Swab the abdomen with the included alcohol pad.

💉
Step 03

Inject before bed

31G insulin syringe, subcutaneous, 10 seconds. Daily Mon–Fri, right before sleep — when your body actually uses growth hormone.

📱
Step 04

Track

Log sleep quality, energy, and training in the portal. Your physician reviews and adjusts your dose as needed.

How We Compare

Why CoreAge Rx Beats The Anti-Aging Clinic Model

Feature⭐ Best ValueCoreAge Rx Overnight ReboundAnti-Aging Clinic (HGH)OTC HGH “Boosters”
Starting price$99$1,500–$3,000/month$30–$100/month
ApproachStimulates your own pituitarySynthetic HGH replacementAmino acid supplements
Auto-billing / subscription trap None — pay per shipmentMembership fees Common
Physician oversight Message any time In-person required None
Compounded per prescription (503A) US-licensedVaries
Cold packed shipped to your door Clinic visits required
Shuts down natural HGH production No — preserves feedback loop Common with long-term use No effect either way
Refund if not approved 100%N/AVaries
Why We Cap Intake

Every Patient Read By A Real Physician Within 24 Hours

That’s not a chatbot screening — that’s a US Board-certified physician reviewing your medical history, your medications, and your goals. To keep that promise, we cap intake based on physician availability. If the cap is reached when you submit, you’ll be added to the next available queue with priority. Either way, you pay nothing until your prescription is approved.

Easy & Accessible

What We Made Easy About Overnight Rebound

🏠

No clinic visits

Intake, prescription, refills, follow-ups — all from your phone.

📦

Cold packed shipping

Refrigerated, temperature-controlled, in unmarked packaging from a 503A pharmacy.

💬

Real physician access

Message your prescribing doctor through the portal. Dose adjustments included.

💰

From $99. Upfront.

No escalators. No tier add-ons. The price you see is the price you pay.

🔄

No auto-billing

Pay per shipment. Order more when you’re ready. No retention traps.

🛡

Free if not approved

The 3-minute intake costs nothing if your physician says it’s not right for you.

Who Overnight Rebound Is For

Who Is CoreAge Rx Overnight Rebound Sermorelin For?

🛠

The Hard Worker

Long days, body never gets a real recovery window. By 45, sleep doesn’t restore you the way it used to.

😴

The Restless Sleeper

You go to bed at 10:30 and still wake up tired. Deep sleep got shallow somewhere along the way. Nothing you’ve tried fixes it.

💪

The Wants-To-Stay-Strong

You’ve watched friends slip after 50 and decided that’s not the plan. You want to keep the muscle, the strength, the energy you have left.

🪞

The Active 40+ Adult

You’re still training, still eating clean, still doing everything right. But the body composition you used to take for granted is moving in the wrong direction.

Honesty First

Who CoreAge Rx Overnight Rebound Is NOT For:

Sermorelin works through your own hormonal system, so there are real contraindications. We’d rather tell you no than risk a bad outcome.

Sermorelin is not for you if:

  • You’re pregnant, breastfeeding, or planning pregnancy
  • You have an active cancer diagnosis (HGH and IGF-1 are contraindicated — discuss with your oncologist)
  • You have active proliferative diabetic retinopathy
  • You’re under 25 (your pituitary is still firing at full capacity)
  • You have severe untreated sleep apnea
  • You’re looking for a dramatic, fast transformation (Sermorelin is gradual, working with your biology)
  • You’re unwilling to inject daily before bed (Mon–Fri)

Your physician makes the final determination during your intake review.

Why We Built This

How The Anti-Aging Clinic Industry Built A $30,000/Year Habit Out Of A $200 Molecule

In 2024, the average synthetic HGH protocol at an anti-aging clinic in the US ran $1,500 to $3,000 a month— plus consultation fees, plus follow-up labs, plus the in-person visits. That’s $20,000 to $40,000 a year.

Sermorelin works through a different mechanism — your body releases its own growth hormone, in its own physiological rhythm, with its own built-in feedback loop. Most patients prefer it. The cost to compound is a tiny fraction of synthetic HGH.

We watched patients pay clinic prices. Then we watched them stop, because they couldn’t justify it. The clinical evidence on Sermorelin is strong. The access model was broken. CoreAge Rx exists to fix the access model — not the medicine.

“Aging well shouldn’t be reserved for the people who can afford a $3,000/month clinic. It should be available to anyone whose physician says yes.”

The Specs

Here’s ExactlyWhat’s In Every Vial

Compounded Sermorelin Injection
Personalized per physician prescription
Active ingredientSermorelin acetate
Concentration3 mg/mL
Vial size5 mL · amber glass
Total medication15 mg per vial
RouteSubcutaneous (Sub-Q), daily (Mon–Fri)
Included needle31G insulin syringe
Supply Options & Shipments
Standard order1 vial · 1 shipment
3-month supply3 vials · 1 shipment
6-month supply3 vials × 2 shipments
12-month supply3 vials × 4 shipments
Compounded & Shipped
Pharmacy503A licensed compounding
StorageRefrigerate 36°F–46°F
ShippingCold Prepped
503A Licensed Pharmacy
👩‍⚕️
US Board-Certified MDs
🧬
Personalized Per Patient
HIPAA Secure
HIPAA Secure
🚫
No Auto-Billing
Pricing

Overnight Rebound At A Fraction Of Clinic Pricing

⭐ Overnight Rebound · CoreAge RxOvernight Rebound · Sermorelin Peptide vial

Overnight Rebound

Sermorelin Peptide · Daily (Mon–Fri) · 3 mg/mL × 5 mL vial

Starting at
$299$99/month

Multi-month savings available at 3 / 6 / 12 months

  • 3 mg/mL × 5 mL amber vial per order
  • Daily subcutaneous injection, Mon–Fri (31G insulin syringe)
  • Full injection kit included
  • Personalized dose set by your physician
  • Physician messaging included — no extra fees
  • No auto-billing. Order each shipment when you want it.
See If I Qualify →

Free if you’re not approved · 100% refund

We never auto-charge your card. You order each refill when you’re ready, and your physician handles dose adjustments at no extra cost.

Patient Reviews

2,000+ Patients. Here’s The Unfiltered Breakdown.

4.6 out of 5based on 2,000+ patient reviews
Verified patient Jennifer H.
Jennifer H. ✓ Verified Patient
Overnight Rebound · 6 months

Easy, thorough, and great price

CoreAge Rx made the whole process easy. The pricing is clearly stated and there are no hidden fees. Six months in, I look and feel better than I have in years. Sleep, energy, body comp — all noticeably different.

Verified patient Terri K.
Terri K. ✓ Verified Patient
Sermorelin · 3 months

Searched several online companies — CoreAge Rx was the best

I took the time to research many online companies offering Sermorelin. After several hours of comparing pricing and credentials, I decided CoreAge Rx was the place. Read the reviews of hundreds of happy customers and decided this would be the best fit. Three months in, no regrets.

Verified patient V Frye
V Frye ✓ Verified Patient
Overnight Rebound · 8 weeks

Truthful about their pricing. No hidden cost.

The CoreAge Rx site was easy to understand, but more importantly was truthful about their prices. NO hidden cost, no surprise auto-billing. Delivery was fast and their customer service is outstanding. The sleep improvement alone is worth it.

Verified patient Simon O.
Simon O. ✓ Verified Patient
Sermorelin · 10 weeks

Flawless. Doctor reached out within hours.

The whole experience getting started went flawlessly. After filling out the paperwork I was contacted by the prescribing doctor within hours to confirm my protocol. At 10 weeks, body composition has visibly shifted and my workouts feel like they’re producing real results again. Highly recommended.

Verified patient Dale M.
Dale M. ✓ Verified Patient
Overnight Rebound · 12 months

A year in — receiving 3 months at once is convenient

I appreciate receiving 3 months of medication in one shipment. The vials are sequentially labeled which helps me track. Excellent service, no auto-billing surprises, and the therapy has changed how I feel at 58. Best money I’ve spent on my health in a decade.

Verified patient Elena P.
Elena P. ✓ Verified Patient
Sermorelin · 4 months

My sleep is the biggest change

I came for the body composition and stayed for the sleep. I had no idea what good sleep felt like until I started waking up before my alarm, refreshed, four months running. Mental clarity through the day. Skin firmer. Highly recommended.

Reviews are unsolicited patient experiences across CoreAge Rx products and have been lightly edited for length. Individual results vary.

Questions We Hear A Lot

The HonestAnswers — Including The Ones We’d Rather Not Give

Does the injection actually hurt?+

Less than you’re imagining. We use a 31G insulin syringe — the smallest available, the same size diabetics use multiple times a day. The injection is subcutaneous (into the fat layer of your abdomen or thigh), not muscular. Most patients describe it as a brief pinch. The 90-second walkthrough video covers technique in detail. By week two, most patients don’t think about it.

How quickly will I feel a difference?+

Sleep improvements often come within the first two weeks. Energy and recovery shift over weeks 3–4. Visible body composition change typically takes 2–3 months to become obvious. The deeper benefits (skin, muscle, sustained energy) compound over months 3 through 12. Sermorelin works through your biology, not around it — that’s why it takes time.

Is compounded Sermorelin FDA approved?+

No, and that’s worth understanding. Compounded medications are prepared at state-licensed compounding pharmacies for individual prescriptions and are not required to go through FDA approval the way mass-manufactured drugs are. The active ingredient (Sermorelin acetate) has decades of clinical research behind it. Our pharmacy is 503A licensed and the pharmacy details appear on your prescription and vial.

What are the side effects?+

Most common: mild flushing, warmth, or redness at the injection site, lasting a few minutes. Less common: brief headache, lightheadedness if you stand up too fast, or tingling on injection nights. Some patients report short-lived feeling of restlessness in the first two weeks as their pituitary adjusts. Rare: nausea. Your physician adjusts dose if any of these persist.

Is Sermorelin the same as synthetic HGH?+

No — that’s the most important distinction. Synthetic HGH (somatropin) replaces growth hormone directly, which can suppress your pituitary’s own production over time and is tightly regulated. Sermorelin signals your pituitary to release its own growth hormone, preserving the body’s natural feedback loop. The effects are similar but milder, the safety profile is better, and the cost is a fraction. Most patients who don’t have a diagnosed adult GH deficiency are far better suited to Sermorelin.

Do I need to cycle on and off?+

Many physicians use a cycling protocol (e.g. 5 days on, 2 days off, or 3 months on followed by a 1-month break) to mimic natural pituitary rhythm and reduce the chance of receptor desensitization. Your CoreAge Rx physician determines what’s right for you based on your goals and bloodwork. There’s no universal answer — it’s part of why personalized prescriptions matter.

What if I'm not approved?+

You pay nothing. The 3-minute intake is free regardless of outcome. If your physician determines Sermorelin isn’t right for you, they’ll explain why and suggest what might be — sometimes a different therapy, sometimes a referral to a primary care provider.

How do I cancel?+

No cancellation necessary. CoreAge Rx doesn’t auto-bill your card. When you’re ready for your next shipment, you order it. When you’re not, you don’t. No subscription traps, no retention calls, no friction.

How does the multi-month supply work?+

A standard order is one 5 mL vial in one shipment. A 3-month supply is 3 vials in one shipment. 6 and 12-month supplies are split into multiple shipments (every 3 months) so your medication stays fresh and refrigerated. You pay upfront for the supply you choose; we don’t charge again until you order again.

You’ve Already Done The Hard Part.

You stopped pretending the slower, softer, tireder version of you was just life now. You did the research. You compared the clinics. You looked at the science.

Overnight Rebound Sermorelin won’t make you twenty-five again. What it will do is tell your pituitary to start producing the molecule it used to produce in abundance — the one your body is still hardwired to release every night while you sleep. The work compounds. Patients tell us by month three they stop measuring. By month six they stop remembering what tired felt like.

The intake is three minutes. A physician reads it within twenty-four hours. If you’re not a candidate, you pay nothing.

See If I Qualify →

Free physician review · No auto-billing · 100% refund if not approved

From $99 · Sermorelin
No auto-billing
See If I Qualify →