A daily peptide (Mon–Fri) that signals your body's own growth hormone — when clinically appropriate. By 40, GH output is roughly half what it was at 20. Most patients feel the shift in sleep depth and recovery by week 2.
| Spec | Overnight Rebound |
|---|---|
| Active ingredient | Sermorelin acetate |
| Peptide | 29-amino-acid GHRH analog |
| Mechanism | Signals the pituitary to release GH |
| Concentration | 3 mg/mL |
| Vial size | 5 mL · amber glass |
| Total medication | 15 mg per vial |
| Route | Subcutaneous (Sub-Q) |
| Included applicator | 31G insulin syringes (every dose included) |
| Frequency | Daily (Mon–Fri), before bed |
| Prescription class | Compounded Rx (503A licensed) |
| Monthly cost | $99 flat — everything included |
Online intake, a real U.S.-licensed provider review, and overnight shipping from a 503A pharmacy. If sermorelin isn't right for you, you're automatically refunded.
Answer a short medical questionnaire about your goals, sleep, recovery, and history. No clinic visit. No waiting room. Pay nothing until a provider approves.
A U.S.-licensed clinician reads your full intake within 24–48 hours. If sermorelin is clinically appropriate, a prescription is issued. If not, you're automatically refunded.
Ships overnight cold-packed from a licensed 503A pharmacy. Self-administered with a 31G insulin syringe before bed — when natural growth hormone release peaks.
Growth hormone is your body's master recovery signal. Released by your pituitary — primarily during deep sleep — it drives tissue repair, lean mass maintenance, fat metabolism, and the kind of rest that actually rebuilds you. Your body makes plenty of it at 25.
By 40, GH output is about half of what it was at 20. By 60, it's about a quarter. This is one of the most well-documented patterns in human aging research.
Sermorelin doesn't replace growth hormone. It mimics the natural GHRH signal your hypothalamus sends to your pituitary — telling it to release GH in your body's own pulsatile, nighttime rhythm.
Sermorelin is a 29-amino-acid copy of the natural GHRH peptide your hypothalamus already produces — not a synthetic hormone.
Triggers growth hormone release in the same rhythm your body used at 25 — not a flat, continuous flood.
GH release peaks during deep sleep — the slow-wave kind that actually rebuilds the body, not the shallow seven hours you're already getting.
Drives the cellular work your body relies on between workouts and through the night — which is why recovery and body composition track together.
Healthy GH levels are tied to body composition — not as a fat-loss drug, but as the underlying signal your metabolism stopped getting.
Because sermorelin works through your existing feedback loops, your body retains control over how much hormone is released and when.
Sermorelin is a cellular signal, not a stimulant. Here's what most patients report on their 6- and 12-month follow-ups.
Most patients notice the depth of sleep changes before energy or recovery. You're still in bed seven hours — but you wake up like you actually slept.
Soreness clears faster. The post-workout drag that took three days now takes one. The fatigue stops stacking through the week.
You wake up rebuilt, not just rested. Morning energy stops being a project. Patients say this is when they stop wondering whether it's working.
Lean mass starts holding. Recovery is consistent. Same workouts respond like they used to — without changing the math underneath them.
Most patients can no longer separate “sermorelin effects” from “how they feel” — it just becomes the new baseline.
Patients describe a felt sense of biological time slowing — not stopping, slowing. The gains hold. This is maintenance, not catch-up.
Sermorelin is available in a handful of places — at very different prices, with very different patient experiences. Here's the honest breakdown.
| Provider / Channel | BEST VALUECoreAge Rx Overnight Rebound | Synthetic HGH | Anti-Aging Clinic | Other Telehealth | OTC "Peptides" |
|---|---|---|---|---|---|
| Mechanism | GHRH signal — your own GH | Direct hormone replacement | Sermorelin or HGH | Varies | Supplement (no Rx) |
| Monthly cost | $99 flat | $1,500–$5,000/mo | $500–$1,500/mo | $200–$400/mo | Not Rx-grade |
| Body's feedback loop | ✓ Pulsatile, natural rhythm | ✗ Bypasses feedback | Depends on therapy | Varies | N/A |
| Prescription class | ✓ Compounded Rx (503A) | Schedule III / restricted | ✓ Rx, in-person | Varies | ✗ Supplement aisle |
| Licensed provider review | ✓ U.S.-licensed clinician | ✓ Required | ✓ In-person only | Varies | ✗ None |
| Supplies included | ✓ Syringes, swabs, guide | Clinic-dependent | ✓ | Often $20–40/mo extra | ✗ Buy separately |
| Cold shipping to your door | ✓ | Clinic ships | ✗ Clinic visit required | ✓ | ✓ |
| Auto-refund if declined | ✓ 100% | N/A | N/A | Varies | N/A |
Anti-aging clinic pricing represents typical 2024 US market rates. Annual cost at $500–$1,500/month: $6,000–$18,000.
Complete your online visit in a few minutes. A U.S.-licensed provider will review your medical history and goals — and decide whether treatment is clinically appropriate. If it's not, you'll be refunded automatically.
Start Your Online Visit — $99/mo Flat →