Firmer-looking skin. Brighter tone. Deeper hydration.
A prescription-strength anti-aging topical - estriol, vitamin C, and hydrolyzed hyaluronic acid - to help improve the appearance of mature, dry, or less-firm skin.*
Time Out is designed for skin that looks dry, dull, thin, or less firm over time. Three prescription-strength actives, each with a job: estriol helps support the look of firmness and elasticity, vitamin C helps brighten uneven tone, and hydrolyzed hyaluronic acid delivers lightweight hydration for skin that looks plumper and more refreshed.* Provider-guided, made in the USA, and never auto-billed.
- ✓ Estriol 0.3% · Vitamin C 5% · Hyaluronic Acid 0.5%
- ✓ Helps improve the look of firmness & elasticity*
- ✓ Brightens dull, uneven-looking tone*
- ✓ Provider-guided · made in the USA
Get started with Time Out
Time Out is designed for skin that looks dry, dull, thin, or less firm over time. Three prescription-strength actives, each with a job: estriol helps support the look of firmness and elasticity, vitamin C helps brighten uneven tone, and hydrolyzed hyaluronic acid delivers lightweight hydration for skin that looks plumper and more refreshed.* Provider-guided, made in the USA, and never auto-billed.
If Your Skin Looks Duller And Less Firm Than It Used To:
- ✕ Skin that looks dull and tired even when you're rested
- ✕ Firmness and bounce that have quietly slipped over the years
- ✕ Dryness and fine lines that makeup settles into
- ✕ Uneven, blotchy-looking tone that no serum seems to touch
- ✕ Drugstore “anti-aging” creams that are mostly fragrance and hope
- ✕ Wondering whether you need something prescription-strength - and where to even get it
Mature skin doesn’t need a cabinet of hopeful creams. It needs prescription-strength actives, chosen and guided by a provider.
Three Prescription-Strength Actives, Three Different Jobs
A prescription-strength active that helps support the appearance of firmness, elasticity, and smoother-looking mature skin.*
Helps brighten the look of dull skin and improve the appearance of uneven tone.*
Lightweight hydration that helps skin look plumper, softer, and more refreshed.*
Prescription-strength actives selected for the visible signs of mature skin. Because estriol is a prescription active, Time Out is provider-guided - reviewed for your health history before it ships, not grabbed off a shelf.
Why Three Actives Beat One “Miracle” Cream
Mature skin usually isn’t one problem - it’s several at once: it looks less firm, more dull, and drier. A single drugstore active can’t address all three, which is why so many creams underwhelm.*
Time Out pairs three actives at prescription strength, each doing a different job: estriol for the look of firmness and elasticity, vitamin C for brightness and the look of uneven tone, and hydrolyzed hyaluronic acid for lightweight hydration that helps skin look plumper.*
It won’t work overnight, and results vary. Because it’s prescription-strength - including estriol, a prescription active - a licensed provider reviews your health history first to decide whether it’s appropriate for you.*
One nightly, prescription-strength topical. Estriol for the look of firmness, vitamin C for brightness, hyaluronic acid for hydration. To help mature skin look firmer, brighter, and more refreshed - over time.*
A provider-guided, prescription-strength formula. Starting at $48/month, never auto-billed.
Six Things We Won’t Compromise On
Prepared By A Licensed Pharmacy, Guided By A Provider
Time Out is a prescription-strength formula. After a licensed provider reviews your intake and health history and determines it’s appropriate, it’s prepared by a licensed pharmacy in the USA and shipped to your door - estriol 0.3%, vitamin C 5%, and hydrolyzed hyaluronic acid 0.5% in a nightly topical for external use.
Time Out may be recommended or prescribed by a licensed provider and dispensed by a pharmacy when appropriate for you.
Apply at night as directed. Avoid the eye area and broken skin. Use daily sunscreen - vitamin C and prescription actives can make skin more sensitive to the sun.
Glow Is A Process, Not An Overnight Switch.*
Prescription-strength actives work with consistency. Here’s roughly how it tends to unfold with nightly use - results vary, and your provider may have you start slowly.
Hydration first.
Hyaluronic acid tends to show up early - skin may look plumper and feel softer. Your provider may have you ease in every other night to build tolerance to the actives.*
A brighter look.
With consistent use, some people say dull, uneven-looking tone starts to look brighter and more even - the vitamin C doing its job.* Results vary.
The look of firmness & texture.
Changes in the appearance of firmness, elasticity, and smoother texture usually need consistent use over weeks to months. This is the window where those tend to become noticeable, if they do.*
A firmer-, brighter-looking baseline.
Keep using it as directed by your provider. Consistency is what supports firmer-, brighter-, more hydrated-looking skin over time.*
Sunscreen protects your progress.
Vitamin C and prescription actives can increase sun sensitivity. Daily SPF is part of the routine, not an afterthought.
*Individual results vary. This page is not medical advice. Follow your provider’s instructions.
What CoreAge Rx Patients Are Saying:
My skin had gone flat and dull in my late 50s. A few months in, it looks brighter and a little firmer to me, and it's not as dry. I like that a provider actually reviewed my history before prescribing it.
The hydration was the first thing I noticed - my skin looked plumper within a couple of weeks. The brightness came later. I started every other night like they suggested so it wouldn't irritate.
I wanted prescription-strength, not another drugstore cream that's mostly perfume. My tone looks more even and my skin looks less tired. Gradual, but I can see it in photos.
The intake asked about my health history in detail, which I appreciated given it's prescription-strength. My skin looks more refreshed and the fine lines don't catch my makeup as much.
No auto-billing was the reason I finally tried it - I reorder when I'm ready instead of getting surprise charges. Skin looks firmer and brighter than it did last year.
I use it at night, sunscreen in the morning like they told me. My cheeks look less crepey and more hydrated. It's one step, which I can actually keep up with.
Individual results vary. Testimonials are unsolicited patient experiences, not typical outcomes or guarantees.
“Aging skin doesn’t need a miracle. It needs the right actives, at prescription strength, guided by someone who checked your history first.”
- The CoreAge Rx Medical TeamSimple Nighttime Support For Mature Skin
Use only as directed by your prescribing provider. Because this formula contains active ingredients, your provider may recommend starting slowly and adjusting based on your skin’s tolerance.
Cleanse at night
Apply to clean, dry skin. Time Out is a nighttime formula.
Apply a thin layer
As directed by your provider. Avoid the eyes and broken skin. Start slowly if advised, and do not use more than prescribed.
Sunscreen by day
Use daily SPF. Vitamin C and prescription actives can increase sun sensitivity.
Usage notes: apply as directed · use on clean, dry skin · avoid contact with eyes and broken skin · use sunscreen during the day · do not use more than prescribed.
Different Skin Goals, Different Formulas
| Your main goal | Time Out MATURE / GLOW | Smooth Move (Renewal) | Bounce Back (Repair & Firm) |
|---|---|---|---|
| Best for | Mature, dull, dry, less-firm-looking skin | Fine lines & texture | Barrier repair & firmness |
| Key actives | Estriol, vitamin C, hyaluronic acid | Tretinoin, niacinamide, vitamin C | Copper peptide |
| Also targets | Brightness + hydration + firmness look | Renewal & smoothing | Barrier & resilience |
| Starting price | $48/mo | $42/mo | $64.99/mo |
These are different formulas for different goals - not better or worse than one another. A provider can help you choose the right one for your skin and history, and some routines combine formulas under provider guidance.
Who Should Talk To A Provider First - Or Skip It:
Time Out contains estriol, a prescription active. That’s exactly why it’s provider-guided. Be upfront in your intake if any of these apply to you.
Tell your provider - this may not be appropriate - if you:
- ✕ Have a personal history of breast, uterine, ovarian, or other hormone-sensitive cancer.
- ✕ Are pregnant, trying to become pregnant, or breastfeeding - do not use.
- ✕ Have a history of blood clots, stroke, or an estrogen-related condition.
- ✕ Have unexplained vaginal bleeding or a known estrogen-dependent condition.
- ✕ Are under 18, or have a known allergy to any ingredient (see the formula details).
- ✕ Use other strong actives (tretinoin, acids, benzoyl peroxide) - combining should be provider-guided.
- ✕ Want an OTC quick fix or an overnight result - this is a gradual, prescription-strength, provider-guided treatment.
Your provider reviews your health history during the intake and decides whether Time Out is appropriate for you. If it isn’t, they may recommend a different option, such as Bounce Back (copper peptide, non-hormonal).
The Mature-Skin Aisle Sells Hope. We Wanted To Sell Actives - Responsibly.
For mature skin, the drugstore answer is a jar of fragrance and marketing, and the medical answer is usually a dermatology visit most people never book. There’s a wide, frustrating gap in between.
Time Out fills it with prescription-strength actives - estriol, vitamin C, and hyaluronic acid - but with the guardrail those actives require: a licensed provider who reviews your health history before anything ships. Because a prescription active like estriol shouldn’t be sold like a moisturizer.
It helps mature skin look firmer, brighter, and more hydrated over time. It’s not a miracle, it’s not hormone therapy, and we won’t pretend otherwise.
“Prescription-strength should mean prescription-level care - not a shopping cart with a hormone in it.”
Exactly What Time Out Is
- Actives
- Estriol 0.3%, Vitamin C 5%, Hydrolyzed Hyaluronic Acid 0.5%
- Form
- Nighttime topical
- Use
- External / topical
- Type
- Prescription-strength
- Dispensing
- Licensed US pharmacy
- Price
- From $48/mo
Directions
Apply a thin layer at night to clean, dry skin as directed by your provider. Start slowly if advised, and do not use more than prescribed. Avoid the eye area. Use sunscreen daily.
Do Not Use
On open, broken, or freshly treated skin unless directed by your provider. Do not use if pregnant or breastfeeding, or if a provider has advised against estrogen-containing products.
If Irritation Occurs
If you have burning, swelling, rash, or irritation that isn’t improving, stop and message the medical team/provider so they can review your symptoms and advise you.
This page is not medical advice. Consult a licensed healthcare provider.
Strength
Guided
0.3%
Pharmacy
Auto-Billing
Get Started In 3 Simple Steps
100% online. A licensed provider reviews your intake and health history, and if Time Out is right for you, it ships to your door.
Take the health questionnaire
A confidential online intake about your skin, goals, and health history. Takes a few minutes.
A licensed provider reviews
US board-certified providers oversee every prescription and screen your history - important for a formula that contains a prescription active.
Fast, free delivery
If a provider grants your prescription, it's prepared and shipped free. No auto-billing - reorder only when you're ready.
Choose Your Supply - Save Up To 36%
Estriol rebuilds skin over months, not days. The longer you stay with it, the more your skin has to show for it - and the lower your per-month price.
- Real prescription estriol
- Estriol 0.3% · vitamin C · hyaluronic acid
- 100% transparent price guarantee
- Free shipping included
- Real prescription estriol
- Estriol 0.3% · vitamin C · hyaluronic acid
- 100% transparent price guarantee
- Free shipping included
- Real prescription estriol
- Estriol 0.3% · vitamin C · hyaluronic acid
- 100% transparent price guarantee
- Free shipping included
- Real prescription estriol
- Estriol 0.3% · vitamin C · hyaluronic acid
- 100% transparent price guarantee
- Free shipping included
100% automatic refund if you are not approved by our licensed physician.
The Honest Answers
You’ve Earned Something Stronger Than A Drugstore Jar.
If your skin looks dull, dry, and less firm than it used to, another fragranced moisturizer isn’t going to move the needle. Prescription-strength actives might - but only the right ones, and only if they’re right for you.
Time Out won’t work overnight, and it isn’t hormone therapy or a miracle. What it is: a provider-guided anti-aging topical - estriol, vitamin C, and hyaluronic acid - to help mature skin look firmer, brighter, and more hydrated over time.
Pick your plan below. From $48/month, never auto-billed.
Prescription-strength · provider-reviewed · no auto-billing
Compounded, prescription-strength formula: Time Out™ (Estriol 0.3%, Vitamin C 5%, Hydrolyzed Hyaluronic Acid 0.5%) is a compounded skincare formula that contains estriol, a prescription active. Compounded medications are not FDA-approved. Time Out is prepared by a licensed pharmacy and made available only after a licensed provider reviews your information and health history and determines the formula is appropriate for you. Prescription products require a consultation with a licensed healthcare provider.
Estriol is a form of estrogen. Do not use if you are pregnant, trying to become pregnant, or breastfeeding. Tell your provider before use if you have a history of breast, uterine, ovarian, or other hormone-sensitive cancer; blood clots or stroke; liver disease; unexplained vaginal bleeding; or any estrogen-dependent or estrogen-related condition. Your provider will determine whether an estrogen-containing topical is appropriate for you.
For external use only. Avoid the eye area. Vitamin C and prescription actives can increase sensitivity to the sun; use a daily sunscreen. Do not apply to open, broken, or freshly treated skin unless directed by your provider. Do not use more than prescribed. Some dryness or irritation can occur, especially when starting; your provider may recommend easing in.
Tell your provider if you have a skin condition (such as eczema, rosacea, or active dermatitis), a known allergy to any ingredient, or if you use other active skincare such as tretinoin, retinol, benzoyl peroxide, or other acids. If you experience burning, swelling, blistering, severe rash, or irritation that is not improving, stop use and contact the medical team/provider.
The information on this page is for educational purposes only and is not medical advice, and Time Out is not hormone replacement therapy. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results vary.
Patient experiences shared on this page are unsolicited and have been lightly edited for length and clarity. They represent personal experiences, not typical outcomes or guarantees.
All medical services, including clinical evaluations, treatment planning, and prescribing decisions, are provided exclusively by the Professional Entities (M & D Integrations Inc d/b/a MD Integrations, MDI Medical Group P.C., and MD Integrations & Wellness Provider Group P.A.), which are independently owned and operated. DSO Fine Shrimp d/b/a CoreAge Rx provides the technology platform and administrative coordination services only. DSO Fine Shrimp d/b/a CoreAge Rx does not provide medical services, does not employ healthcare providers, does not participate in clinical decisions, and does not practice medicine.
CoreAge Rx is committed to making its website accessible to all users, including individuals with disabilities, in compliance with the ADA and Section 508 of the Rehabilitation Act. If you have difficulty accessing any content, contact support@coreagerx.com or +1 307-405-1638.
Distributed by CoreAge Rx, 1309 Coffeen Avenue STE 1200, Sheridan, Wyoming 82801 · +1 307-405-1638 · support@coreagerx.com.
Prescription products are available only through consultation with a licensed healthcare provider and require a valid prescription. Individual results may vary. Consult a licensed health professional before starting any treatment. Offers available only to residents of the United States aged 18 and older. DSO Fine Shrimp LLC d/b/a CoreAge Rx is LegitScript-certified.